702361006: Crouzon syndrome with acanthosis nigricans (disorder)

SNOMED CT Concept\Clinical finding (finding)\...

\Head finding (finding)\Finding of head region\Finding of face\Disorder of face (disorder)\Congenital anomaly of face (disorder)\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Head finding (finding)\Cranial suture finding\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Head finding (finding)\Cranial suture finding\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Head finding (finding)\Disorder of head (disorder)\Disorder of face (disorder)\Congenital anomaly of face (disorder)\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Head finding (finding)\Disorder of head (disorder)\Congenital anomaly of head\Congenital anomaly of face (disorder)\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Head finding (finding)\Disorder of head (disorder)\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Head finding (finding)\Disorder of head (disorder)\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)

\Functional finding\Abnormal keratinization\Disorder of keratinisation\Acanthosis nigricans (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)

\Integumentary system finding\Disorder of integument\Hereditary disorder of the integument\Crouzon syndrome with acanthosis nigricans (disorder)
\Integumentary system finding\Disorder of integument\Disorder of keratinisation\Acanthosis nigricans (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Integumentary system finding\Abnormal keratinization\Disorder of keratinisation\Acanthosis nigricans (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)

\Musculoskeletal finding\Joint finding\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Joint finding\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Joint finding\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Joint finding\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Joint finding\Cranial suture finding\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Joint finding\Cranial suture finding\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Disorder of musculoskeletal system\Hereditary disorder of musculoskeletal system\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Disorder of musculoskeletal system\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Musculoskeletal finding\Disorder of musculoskeletal system\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)

\Disease\Disorder of joint region\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of joint region\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of joint region\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of joint region\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Genetic disease\Hereditary disease\Hereditary disorder by system\Hereditary disorder of musculoskeletal system\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Genetic disease\Hereditary disease\Hereditary disorder by system\Hereditary disorder of the integument\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Genetic disease\Hereditary disease\Developmental hereditary disorder\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Genetic disease\Hereditary disease\Autosomal hereditary disorder\Autosomal dominant hereditary disorder\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of foetus and/or newborn\Congenital disease (disorder)\Congenital malformation\Congenital malformation syndrome (disorder)\Multiple system malformation syndrome\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of foetus and/or newborn\Congenital disease (disorder)\Congenital malformation\Congenital anomaly of head\Congenital anomaly of face (disorder)\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of foetus and/or newborn\Congenital disease (disorder)\Congenital malformation\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of foetus and/or newborn\Congenital disease (disorder)\Congenital malformation\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of foetus and/or newborn\Congenital disease (disorder)\Congenital malformation\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of foetus and/or newborn\Congenital disease (disorder)\Congenital malformation\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Hereditary disorder by system\Hereditary disorder of musculoskeletal system\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Hereditary disorder by system\Hereditary disorder of the integument\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of integument\Hereditary disorder of the integument\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of integument\Disorder of keratinisation\Acanthosis nigricans (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of musculoskeletal system\Hereditary disorder of musculoskeletal system\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Lesion of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of musculoskeletal system\Disorder of skeletal system\Arthropathy (disorder)\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of musculoskeletal system\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of body system\Disorder of musculoskeletal system\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of head (disorder)\Disorder of face (disorder)\Congenital anomaly of face (disorder)\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of head (disorder)\Congenital anomaly of head\Congenital anomaly of face (disorder)\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of head (disorder)\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Disorder of head (disorder)\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Developmental disorder\Developmental hereditary disorder\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Developmental disorder\Congenital malformation\Congenital malformation syndrome (disorder)\Multiple system malformation syndrome\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Developmental disorder\Congenital malformation\Congenital anomaly of head\Congenital anomaly of face (disorder)\Multiple malformation syndrome with facial defects as major feature\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Developmental disorder\Congenital malformation\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Developmental disorder\Congenital malformation\Congenital anomaly of head\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Developmental disorder\Congenital malformation\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Fibroblast growth factor receptor 3-related craniosynostosis (disorder)\Crouzon syndrome with acanthosis nigricans (disorder)
\Disease\Developmental disorder\Congenital malformation\Congenital anomaly of musculoskeletal system\Congenital anomaly of joint\Imperfect fusion of skull\Craniosynostosis syndrome\Crouzon syndrome\Crouzon syndrome with acanthosis nigricans (disorder)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jul 2014. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

2995059010 Crouzon syndrome with acanthosis nigricans (disorder) en Fully specified name Active Entire term case sensitive (core metadata concept) SNOMED CT core

2995457019 Crouzon syndrome with acanthosis nigricans en Synonym (core metadata concept) Active Entire term case sensitive (core metadata concept) SNOMED CT core

3010153011 Crouzonodermoskeletal syndrome en Synonym (core metadata concept) Active Entire term case sensitive (core metadata concept) SNOMED CT core

4022295011 A distinct form of Crouzon disease associated with acanthosis nigricans caused by a specific mutation (p.Ala391Glu) in the transmembrane domain of FGFR3. The disease is transmitted in an autosomal dominant manner with variable penetrance. en Definition Active Entire term case sensitive (core metadata concept) SNOMED CT core

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Crouzon syndrome with acanthosis nigricans (disorder)	Is a	Autosomal dominant hereditary disorder	false	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Is a	Acanthosis nigricans (disorder)	true	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Is a	Hereditary disorder of musculoskeletal system	false	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Is a	Crouzon syndrome	true	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Is a	Hereditary disorder of the integument	true	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Finding site	Skin structure	false	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Has definitional manifestation	Abnormal keratinization	false	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Finding site	Face structure	false	Inferred relationship	Some	6
Crouzon syndrome with acanthosis nigricans (disorder)	Occurrence	Congenital	false	Inferred relationship	Some	6
Crouzon syndrome with acanthosis nigricans (disorder)	Associated morphology	Developmental anomaly	false	Inferred relationship	Some	6
Crouzon syndrome with acanthosis nigricans (disorder)	Occurrence	Congenital	false	Inferred relationship	Some	5
Crouzon syndrome with acanthosis nigricans (disorder)	Associated morphology	Congenital premature fusion	false	Inferred relationship	Some	5
Crouzon syndrome with acanthosis nigricans (disorder)	Finding site	Joint structure of suture of skull	false	Inferred relationship	Some	5
Crouzon syndrome with acanthosis nigricans (disorder)	Is a	Connective tissue hereditary disorder (disorder)	false	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Finding site	Bone structure of cranium	false	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Finding site	Structure of integumentary system (body structure)	true	Inferred relationship	Some	4
Crouzon syndrome with acanthosis nigricans (disorder)	Has interpretation	Abnormal	true	Inferred relationship	Some	1
Crouzon syndrome with acanthosis nigricans (disorder)	Interprets	Keratinization	true	Inferred relationship	Some	1
Crouzon syndrome with acanthosis nigricans (disorder)	Associated morphology	Congenital premature fusion	false	Inferred relationship	Some	3
Crouzon syndrome with acanthosis nigricans (disorder)	Finding site	Joint structure of suture of skull	true	Inferred relationship	Some	3
Crouzon syndrome with acanthosis nigricans (disorder)	Pathological process (attribute)	Pathological developmental process	true	Inferred relationship	Some	2
Crouzon syndrome with acanthosis nigricans (disorder)	Associated morphology	Morphologically abnormal structure (morphologic abnormality)	true	Inferred relationship	Some	2
Crouzon syndrome with acanthosis nigricans (disorder)	Occurrence	Congenital	true	Inferred relationship	Some	3
Crouzon syndrome with acanthosis nigricans (disorder)	Pathological process (attribute)	Pathological developmental process	true	Inferred relationship	Some	3
Crouzon syndrome with acanthosis nigricans (disorder)	Occurrence	Congenital	true	Inferred relationship	Some	2
Crouzon syndrome with acanthosis nigricans (disorder)	Finding site	Face structure	true	Inferred relationship	Some	2
Crouzon syndrome with acanthosis nigricans (disorder)	Is a	Fibroblast growth factor receptor 3-related craniosynostosis (disorder)	true	Inferred relationship	Some
Crouzon syndrome with acanthosis nigricans (disorder)	Associated morphology	Premature fusion	true	Inferred relationship	Some	3

Inbound Relationships

Type

Active

Source

Characteristic

Refinability

Group

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
2995059010	Crouzon syndrome with acanthosis nigricans (disorder)	en	Fully specified name	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
2995457019	Crouzon syndrome with acanthosis nigricans	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
3010153011	Crouzonodermoskeletal syndrome	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
4022295011	A distinct form of Crouzon disease associated with acanthosis nigricans caused by a specific mutation (p.Ala391Glu) in the transmembrane domain of FGFR3. The disease is transmitted in an autosomal dominant manner with variable penetrance.	en	Definition	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core