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372917005: Substance with protein-tyrosine kinase inhibitor mechanism of action (substance)

SNOMED CT Concept\Substance\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Transferase inhibitor\Phosphotransferase inhibitor\Protein kinase inhibitor\Protein-tyrosine kinase inhibitor

Status: current, Sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2018. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Protein-tyrosine kinase inhibitor	Is a	Antineoplastic agent (substance)	false	Inferred relationship	Some
Protein-tyrosine kinase inhibitor	Is a	Epidermal growth factor receptor inhibitor	false	Inferred relationship	Some
Protein-tyrosine kinase inhibitor	Is a	Protein kinase inhibitor	true	Inferred relationship	Some
Protein-tyrosine kinase inhibitor	Has disposition (attribute)	Protein-tyrosine kinase inhibitor (disposition)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Imatinib mesilate	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Product containing protein-tyrosine kinase inhibitor (product)	Has active ingredient	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some	1
Product containing imatinib (medicinal product)	Has active ingredient	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Product containing gefitinib (medicinal product)	Has active ingredient	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Gefitinib 250 mg oral tablet	Has active ingredient	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Iressa 250mg tablet	Has active ingredient	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
imatinib 100 mg, kapsel	Has active ingredient	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Gefitinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
imatinib 400 mg, tablett	Has active ingredient	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Imatinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Erlotinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Vandetanib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Sunitinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Sorafenib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Dasatinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Lapatinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Nilotinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Axitinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Pazopanib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Toceranib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Regorafenib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Ruxolitinib	Is a	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Bosutinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Ceritinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Afatinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Crizotinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Ponatinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Epidermal growth factor receptor inhibitor	Is a	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Janus kinase inhibitor	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Non-specific protein-tyrosine kinase inhibitor	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Lenvatinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Cobimetinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Alectinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Cabozantinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Midostaurin	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Tivozanib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Neratinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Brigatinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Erlotinib hydrochloride (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Nilotinib hydrochloride monohydrate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Ponatinib hydrochloride (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Sunitinib malate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Sorafenib tosylate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Toceranib phosphate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Afatinib dimaleate	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Bosutinib monohydrate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Pazopanib hydrochloride (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Cobimetinib fumarate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Fostamatinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Lenvatinib mesilate	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Neratinib maleate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Rho-associated protein kinase inhibitor	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Dacomitinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Alectinib hydrochloride (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Gilteritinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Lorlatinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Larotrectinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Nilotinib hydrochloride (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Lapatinib ditosylate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Lapatinib ditosylate monohydrate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Human epidermal growth factor receptor 2 inhibitor	Is a	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Erdafitinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Pexidartinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Entrectinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Cabozantinib s-malate	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Tucatinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Pemigatinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Capmatinib (substance)	Is a	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Selpercatinib	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Ripretinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Pralsetinib (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Tirbanibulin	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Tepotinib	Is a	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Tepotinib hydrochloride	Is a	False	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Dacomitinib monohydrate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Mesenchymal epithelial transition inhibitor	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Tivozanib hydrochloride	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some
Tivozanib hydrochloride monohydrate (substance)	Is a	True	Protein-tyrosine kinase inhibitor	Inferred relationship	Some

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
1211435017	Protein-tyrosine kinase inhibitor	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3520810019	Substance with protein-tyrosine kinase inhibitor mechanism of action (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3559306016	Substance with protein-tyrosine kinase inhibitor mechanism of action	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2872881000052110	proteintyrosinkinashämmare	sv	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Sweden NRC maintained module (core metadata concept)