402642005: Acne with gram negative folliculitis (disorder)

SNOMED CT Concept\Clinical finding\...

\Skin AND/OR mucosa finding\Skin or mucosa lesion\Lesion of skin and/or skin-associated mucous membrane\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Hair follicle finding\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Disorder of skin appendage\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Disorder of skin appendage\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Skin AND/OR mucosa finding\Skin finding\Disorder of skin\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis

\General finding of soft tissue\Skin finding\Hair follicle finding\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Disorder of skin appendage\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Disorder of skin appendage\Acne\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Skin finding\Disorder of skin\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Soft tissue lesion\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Soft tissue infection\Infection of skin and/or subcutaneous tissue\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Soft tissue infection\Infection of skin and/or subcutaneous tissue\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Acne\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\General finding of soft tissue\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis

\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Hair follicle finding\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Disorder of skin appendage\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Disorder of skin appendage\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Integumentary system finding\Skin finding\Disorder of skin\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis

\Disease\Disorder of body system\Inflammation of specific body systems\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of body system\Inflammation of specific body systems\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Inflammation of specific body systems\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Skin or mucosa lesion\Lesion of skin and/or skin-associated mucous membrane\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of body system\Disorder of integument\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Inflammatory disorder\Inflammation of specific body structures or tissue\Inflammation of specific body systems\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Inflammatory disorder\Inflammation of specific body structures or tissue\Inflammation of specific body systems\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Inflammatory disorder\Inflammation of specific body structures or tissue\Inflammation of specific body systems\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Inflammatory disorder\Inflammation of specific body structures or tissue\Inflammation of specific body organs\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Inflammatory disorder\Inflammation of specific body structures or tissue\Inflammation of specific body organs\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Inflammatory disorder\Inflammation of specific body structures or tissue\Inflammation of specific body organs\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Infection\Soft tissue infection\Infection of skin and/or subcutaneous tissue\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Infection\Soft tissue infection\Infection of skin and/or subcutaneous tissue\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Infection\Bacterial infection\Disease caused by Gram-negative bacteria\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Infection\Bacterial infection\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Soft tissue lesion\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Soft tissue infection\Infection of skin and/or subcutaneous tissue\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Soft tissue infection\Infection of skin and/or subcutaneous tissue\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Inflammation of skin and/or subcutaneous tissue\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Inflammatory dermatosis\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Hair follicle disorder\Folliculitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Disorder of skin appendage\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Disorder of skin\Skin lesion\Acne\Inflammatory acne\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Infective dermatitis\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis
\Disease\Disorder of soft tissue\Disorder of skin and/or subcutaneous tissue\Infection of skin and/or subcutaneous tissue\Infection of skin\Bacterial infection of skin\Bacterial folliculitis\Gram-negative folliculitis\Acne with gram negative folliculitis

Status: current, Primitive. Date: 31-Jul 2003. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

1770566012 Acne with gram negative folliculitis (disorder) en Fully specified name Active Case insensitive SNOMED CT core

1781754017 Acne with gram negative folliculitis en Synonym Active Case insensitive SNOMED CT core

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Acne with gram negative folliculitis	Is a	Gram-negative folliculitis	true	Inferred relationship	Some
Acne with gram negative folliculitis	Pathological process	Infectious process	true	Inferred relationship	Some	1
Acne with gram negative folliculitis	Associated morphology	Inflammatory lesion	true	Inferred relationship	Some	1
Acne with gram negative folliculitis	Finding site	Hair follicle structure	true	Inferred relationship	Some	1
Acne with gram negative folliculitis	Causative agent	Gram-negative bacterium	true	Inferred relationship	Some	1
Acne with gram negative folliculitis	Is a	Inflammatory acne	true	Inferred relationship	Some
Acne with gram negative folliculitis	Is a	Acne	false	Inferred relationship	Some
Acne with gram negative folliculitis	Finding site	Skin structure	false	Inferred relationship	Some
Acne with gram negative folliculitis	Finding site	Sebaceous gland structure	false	Inferred relationship	Some	1
Acne with gram negative folliculitis	Associated morphology	Eruption	false	Inferred relationship	Some	1
Acne with gram negative folliculitis	Finding site	Pilosebaceous apparatus structure	false	Inferred relationship	Some	1
Acne with gram negative folliculitis	Finding site	Pilosebaceous apparatus structure	false	Inferred relationship	Some	1
Acne with gram negative folliculitis	Associated morphology	Eruption	false	Inferred relationship	Some	1
Acne with gram negative folliculitis	Finding site	Skin appendage structure	false	Inferred relationship	Some	1
Acne with gram negative folliculitis	Associated morphology	Eruption	false	Inferred relationship	Some	1

Inbound Relationships

Type

Active

Source

Characteristic

Refinability

Group

Reference Sets

Disease caused by microorganism or bacterial toxin reference set

Australian emergency department reference set

Clinical finding foundation reference set

Problem/Diagnosis reference set