900000000000526001: REPLACED BY association reference set (foundation metadata concept)

SNOMED CT Concept\SNOMED CT Model Component\Foundation metadata concept (foundation metadata concept)\Reference set\Association type\Historical association reference set (foundation metadata concept)\REPLACED BY association reference set (foundation metadata concept)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT model component module (core metadata concept)

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
REPLACED BY association reference set (foundation metadata concept)	Is a	Historical association reference set (foundation metadata concept)	true	Inferred relationship	Some

Members	targetComponentId
pT3a: Tumor invades perivesical tissue microscopically (urinary bladder)	American Joint Committee on Cancer pT3a (qualifier value)
pT3a: Tumor more than 5 cm in greatest dimension, limited to dermis or not more than 2 mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas)	American Joint Committee on Cancer pT3a (qualifier value)
pT3b (IIIB): Involvement of vagina (direct extension or metastasis), rectal or bladder wall (without mucosal involvement), or pelvic wall(s) (frozen pelvis) (TNM category and FIGO stage) (corpus uteri)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b (IIIB): Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension (TNM category and FIGO stage) (ovary)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b (IIIB): Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney (TNM category and FIGO stage) (uterine cervix)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b (IIIB): Tumor involves one or both fallopian tubes, with macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension (TNM category and FIGO stage) (fallopian tube)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b category	American Joint Committee on Cancer pT3b (qualifier value)
pT3b: Melanoma 2.01 to 4.0 mm in thickness, with ulceration (melanoma of the skin)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b: Seminal vesicle invasion (prostate)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b: Tumor grossly extends into the renal vein or its segmental (muscle-containing) branches, or vena cava below the diaphragm (kidney)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b: Tumor invades perivesical tissue macroscopically (extravesical mass) (urinary bladder)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b: Tumor massively invades the choroid (retinoblastoma)	American Joint Committee on Cancer pT3b (qualifier value)
pT3b: Tumor more than 5 cm in greatest dimension, limited to dermis and greater than 2 mm in thickness, but not more than 6 mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas)	American Joint Committee on Cancer pT3b (qualifier value)
pT3c (IIIC): Tumor involves one or both fallopian tubes, with peritoneal metastasis outside the pelvis more than 2 cm in diameter (TNM category and FIGO stage) (fallopian tube)	pT3c
pT3c AND/OR N1 (IIIC): Peritoneal metastasis beyond pelvis more than 2 cm in greatest dimension AND/OR regional lymph node metastasis (TNM category and FIGO stage) (ovary)	pT3c
pT3c and/or N1 (IIIC): Tumor involves one or both fallopian tubes, with peritoneal metastasis outside the pelvis more than 2 cm in diameter AND/OR regional lymph node metastasis (TNM category and FIGO stage) (fallopian tube)	pT3c
pT3c category	pT3c
pT3c: Tumor grossly extends into vena cava above diaphragm or invades the wall of the vena cava (kidney)	pT3c
pT3c: Tumor invades the optic nerve through the level of the lamina cribrosa but not to the line of resection and massively invades the choroid (retinoblastoma)	pT3c
pT3c: Tumor more than 5 cm in greatest dimension, invading the subcutis and/or greater than 6 mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas)	pT3c
pT3d category	American Joint Committee on Cancer pT3d (qualifier value)
pT4 (IVA): Tumor invades any of the following: upper urethra, bladder mucosa, rectal mucosa, or is fixed to the pubic bone (TNM category and FIGO stage) (vulva)	American Joint Committee on Cancer pT4 (qualifier value)
pT4 (IVA): Tumor invades bladder mucosa and/or bowel mucosa (TNM category and FIGO stage) (corpus uteri)	American Joint Committee on Cancer pT4 (qualifier value)
pT4 (IVA): Tumor invades mucosa of bladder or rectum and/or extends beyond true pelvis (bullous edema is not sufficient evidence to classify a tumor as pT4) (TNM category and FIGO stage) (uterine cervix)	American Joint Committee on Cancer pT4 (qualifier value)
pT4 (IVA): Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4) (TNM category and FIGO stage) (vagina)	American Joint Committee on Cancer pT4 (qualifier value)
stade pT4	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Extraocular tumor extension which includes sites as per American Joint Committee on Cancer 6th Edition definition (retinoblastoma)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Invasion of bladder AND/OR rectum (prostate)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Melanoma greater than 4.0 mm in thickness, with or without ulceration (melanoma of the skin)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor directly invades other organs or structures and/or perforates visceral peritoneum (appendix)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor directly invades other organs or structures and/or perforates visceral peritoneum (colon/rectum)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades adjacent organs, or through the kidney into the perinephric fat (renal pelvis and ureter)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades adjacent structures (esophagus)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades adjacent structures (stomach)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades any of the following: main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall (extrahepatic bile ducts)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades any of the following: prostate, uterus, vagina, pelvic wall, abdominal wall (urinary bladder)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades beyond Gerota's fascia (kidney)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades deep extradermal structures (i.e. cartilage, skeletal muscle, or bone) (carcinoma of skin excluding eyelid, vulva, penis, and melanomas)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades main portal vein or hepatic artery or invades two or more extrahepatic organs or structures (gallbladder)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades peripancreatic soft tissues or other adjacent organs or structures (ampulla of Vater)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion (testis)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor involves any of the ipsilateral pleural surfaces plus additional sites as by American Joint Committee on Cancer 6th Edition definition (thoracic mesothelioma)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor involves the celiac axis or the superior mesenteric artery (exocrine pancreas)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor more than 16 mm in greatest diameter and/or greater than 10 mm in maximum height (thickness) with extraocular extension (ciliary body and choroid) (uveal melanoma)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor of any size invades adjacent organ(s), e.g., vagina, urethra, bladder (anal canal)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor of any size with direct extension to chest wall or skin (breast)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor of lung as per American Joint Committee on Cancer 6th Edition definition (lung)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor perforates the visceral peritoneum or directly invades other organs or structures (small intestine)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor with extraocular extension (iris) (uveal melanoma)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor with intracranial extension, and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, orbit, or masticator space (nasopharynx)	American Joint Committee on Cancer pT4 (qualifier value)
pT4: Tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum (liver, including intrahepatic bile ducts)	American Joint Committee on Cancer pT4 (qualifier value)
pT4a category	pT4a
pT4a: Intrathyroidal anaplastic carcinoma - surgically resectable (anaplastic carcinoma) (thyroid)	pT4a
pT4a: Melanoma greater than 4.0 mm in thickness, no ulceration (melanoma of the skin)	pT4a
pT4a: Tumor directly invades other organs or structures (colon/rectum)	pT4a
pT4a: Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses (maxillary sinus)	pT4a
pT4a: Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses (nasal cavity and ethmoid sinus)	pT4a
pT4a: Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus) (larynx, subglottis)	pT4a
pT4a: Tumor invades deep extradermal structures (i.e. cartilage, skeletal muscle, or bone) not more than 6mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas)	pT4a
pT4a: Tumor invades prostate or uterus or vagina (urinary bladder)	pT4a
pT4a: Tumor invades skin, mandible, ear canal, and/or facial nerve (major salivary glands)	pT4a
pT4a: Tumor invades the larynx, deep/extrinsic muscle of tongue, medial pterygoid muscle, hard palate, or mandible (oropharynx)	pT4a
pT4a: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose (lip)	pT4a
pT4a: Tumor invades through cortical bone, into deep (extrinsic) muscle of tongue (genioglossus, hyoglossus, palatoglossus, and styloglossus), maxillary sinus, or skin of face (oral cavity)	pT4a
pT4a: Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus) (larynx, supraglottis)	pT4a
pT4a: Tumor invades through thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep intrinsic muscle of the tongue, strap muscles, thyroid, or esophagus) (larynx, glottis)	pT4a
pT4a: Tumor invades thyroid/cricoid cartilage, hyoid bone, thyroid gland, esophagus or central compartment of soft tissue (hypopharynx)	pT4a
pT4a: Tumor of any size extending beyond the thyroid capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve (thyroid)	pT4a
pT4a: Tumor of any size with extension to chest wall, not including pectoralis muscle (breast)	pT4a
pT4a: Tumor penetrates to surface of visceral peritoneum (colon/rectum)	pT4a
pT4b category	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Extrathyroidal anaplastic carcinoma - surgically unresectable (anaplastic carcinoma) (thyroid)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Melanoma greater than 4.0 mm in thickness, with ulceration (melanoma of the skin)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor directly invades or is adherent to other organs or structures (colon/rectum)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus (maxillary sinus)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus (nasal cavity and ethmoid sinus)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades deep extradermal structures (i.e. cartilage, skeletal muscle, or bone) greater than 6mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery (oropharynx)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases internal carotid artery (oropharynx)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades pelvic wall or abdominal wall (urinary bladder)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels (thyroid)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures (hypopharynx)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, glottis)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, subglottis)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, supraglottis)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor invades skull base and/or pterygoid plates and/or encases carotid artery (major salivary glands)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor involves masticator space, pterygoid plates, or skull base and/or encases internal carotid artery (lip and oral cavity)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor involves masticator space, pterygoid plates, or skull base and/or encases internal carotid artery (oropharynx)	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor of any size with edema (including peau d'orange) or ulceration of the skin of the breast or satellite skin nodules confined to the same breast	American Joint Committee on Cancer pT4b (qualifier value)
pT4b: Tumor penetrates visceral peritoneum (colon/rectum)	American Joint Committee on Cancer pT4b (qualifier value)
pT4c category	pT4c
pT4c: Tumor of any size with direct extension to chest wall (not including pectoralis muscle) and edema (including peau d'orange) or ulceration of the skin of the breast or satellite skin nodules confined to the same breast	pT4c
pT4d category	American Joint Committee on Cancer pT4d (qualifier value)
pT4d: Inflammatory carcinoma (breast)	American Joint Committee on Cancer pT4d (qualifier value)
stade pTX	pTX
pTX: Primary tumor cannot be assessed (breast)	pTX
pTX: Primary tumor cannot be assessed, or tumor proven by the presence of malignant cells in sputum or bronchial washings but not visualized by imaging or bronchoscopy (lung)	pTX
carcinome papillaire non-invasif du tractus urinaire	pTa
stade pTis	American Joint Committee on Cancer pTis (qualifier value)
pTis: Carcinoma in situ (breast)	American Joint Committee on Cancer pTis (qualifier value)
pTis: Carcinoma in situ	American Joint Committee on Cancer pTis (qualifier value)

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Reference Sets

Reference set descriptor

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Id	Description	Lang	Type	Status	Case?	Module
900000000001156010	REPLACED BY association reference set (foundation metadata concept)	en	Fully specified name	Active	Entire term case sensitive (core metadata concept)	SNOMED CT model component module (core metadata concept)
900000000001157018	REPLACED BY association reference set	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT model component module (core metadata concept)
7237811000172118	referentieset voor associaties betreffende vervangende concepten	nl	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Belgian module (core metadata concept)