| Inbound Relationships | 
Type | 
Active | 
Source | 
Characteristic | 
Refinability | 
Group | 
| Tis: Intratubular germ cell neoplasia (carcinoma in situ, testis) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| N3: Metastasis in lymph node(s) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T2a (IIA): Endometrial tumor with endocervical glandular involvement | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1: Tumor invades submucosa (colon/rectum) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T4: Thyroid tumor of any size extending beyond the thyroid capsule | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3: Tumor confluent with or extending into the ciliary body and/or choroid with scleral extension (iris) (uveal melanoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor present within 1mm of optic disc (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| No direct extension of malignant neoplasm identified (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Density below reference range | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| pT1: Tumor invades lamina propria or submucosa (esophagus) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Pulmonary parenchymal invasion by tumor indeterminate (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| Insufficient tissue to assess highest pT category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| stade N0 | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Low grade (well to moderately differentiated) (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases internal carotid artery (oropharynx) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM1b: Distant metastasis to bone(s) (prostate) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN3a: Metastasis in 10 or more axillary lymph nodes (at least one tumor deposit greater than 2.0 mm), or metastasis to infraclavicular lymph nodes (breast) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN2 (IVB): Bilateral regional lymph node metastasis (pT1-pT4, pM1) (TNM category and FIGO stage) (vulva) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Uveal melanoma TNM finding | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T2: Aerodigestive tract tumor invades mucosa of >1 adjacent subsite of supraglottis/glottis/region outside supraglottis, (mucosa of base of tongue/vallecula/medial wall of piriform sinus) without fixation of larynx | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T4: Lung tumor of any size with a malignant pleural effusion | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN2: Metastasis in the subcarinal lymph node(s) and/or the ipsilateral internal mammary or mediastinal lymph node(s) (thoracic mesothelioma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM1c category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor stage T4d | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Visceral pleura invasion by tumor absent (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| G2 grade (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1a: Tumor limited to the iris (not more than 3 clock hours in size) (iris) (uveal melanoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| N3: Metastasis in >15 perigastric lymph nodes | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN1c: Metastasis in more than 7 regional lymph nodes (esophagus) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1: Tumor limited to ampulla of Vater or sphincter of Oddi (ampulla of Vater) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN1 (IIIC): Regional lymph node metastasis (TNM category and FIGO stage) (fallopian tube) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| International Federation of Gynecology and Obstetrics cervical cancer (FIGO CC) stage IVA | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Gleason grade score 4 out of 10 (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| L1 stage | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Lymphatic (small vessel) tumor invasion finding (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| Regression involving less than 75 percent of tumour, present | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN1a category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Primary site synchronous tumours present | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM1b (IV): Distant metastasis other than lung (TNM category and FIGO stage) (gestational trophoblast) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1: Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility (larynx, glottis) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Heart involved by direct extension of malignant neoplasm (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Pulmonary parenchymal invasion by tumor absent (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| Tumor surgically unresectable (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3: Tumor more than 5 cm in greatest dimension (carcinoma of skin excluding eyelid, vulva, penis, and melanomas) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3: Tumor invades the liver, gallbladder, pancreas, and/or ipsilateral branches of the portal vein (right or left) or hepatic artery (right or left) (extrahepatic bile ducts) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| M1a (IIIC): gestational trophoblastic tumor extends to the lungs with or without genital tract involvement with two risk factors | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Regression of tumor absent (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| stade pMX | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1: Tumor involves ipsilateral parietal pleura, with or without focal involvement of visceral pleura (thoracic mesothelioma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T2b (IIB): Tumor of uterine cervix, T2 with parametrial invasion | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN2: Metastasis in more than one regional lymph node (kidney) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor stage T1mic | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT4: Tumor directly invades other organs or structures and/or perforates visceral peritoneum (appendix) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN2: Metastasis in 4 to 9 axillary lymph nodes, or in clinically apparent internal mammary lymph nodes in the absence of axillary lymph node metastasis (breast) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT2a (IIA): Extension to AND/OR implants on uterus AND/OR tube(s). No malignant cells in ascites or peritoneal washings (TNM category and FIGO stage) (ovary) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor size after sectioning cannot be determined (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Gleason grade score 7 out of 10 (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor size not applicable (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery (oropharynx) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades subcutaneous tissue (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| N2b: Metastasis in multiple ipsilateral lymph nodes, none > 6 cm in greatest dimension | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Erosion of esophageal tumor into trachea (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 4 | 
| Visceral pleura invasion by tumor not applicable (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| pM1b: Distant metastasis to sites other than bone marrow (retinoblastoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Urinary bladder, ureter, or renal pelvis TNM finding | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT4a: Melanoma greater than 4.0 mm in thickness, no ulceration (melanoma of the skin) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion (testis) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Finding of lesion (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor stage T3bii | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM1: Distant metastasis, includes separate tumor nodule(s) in a different lobe (ipsilateral or contralateral) (lung) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Clinical stage II | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Epithelial ovarian tumour, FIGO stage IVA | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| FIGO VC stade II | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Clark melanoma level 4 | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T1 (I): Endometrial tumor confined to corpus uteri | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Intergroup rhabdomyosarcoma study post-surgical clinical group not applicable (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN0(i+): No regional lymph node metastasis histologically, positive morphologic findings for isolated tumor cells, no cluster greater than 0.2 mm (breast) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT2: Tumor limited to the testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis (testis) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor location cannot be determined (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN1 (IVB): Pelvic or inguinal lymph node metastasis (pT1-pT4, pM1) (TNM category and FIGO stage) (vagina) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T4 (IVA): Tumor of uterine cervix/vagina invades mucosa of bladder or rectum and/or extends beyond true pelvis | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| N1: Regional lymph node metastasis | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Synchronous primary carcinomas (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T1c: Tumor identified by needle biopsy because of elevated prostate specific antigen: PROSTATE: Biopsy/transurethral resection: PROSTATE: Resection | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Venous vessels outside tumor uninvolved by tumor (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| T1 (I): Tumor limited to fallopian tube(s) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Perivesical fat involved by direct extension of malignant neoplasm (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T1 (I): Cervical carcinoma confined to uterus | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT4d: Inflammatory carcinoma (breast) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN3a: Metastasis in a lymph node(s), more than 6 cm in dimension (nasopharynx) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Gleason Score 8-10: Poorly differentiated (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Hypopharyngeal TNM finding | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T2: Stomach tumor invades muscularis propria or subserosa | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| FIGO ovarian tumour stage finding | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T3 (III): Endometrial tumor with local and/or regional spread as specified in T3a, b, N1 and FIGO IIIA, B, and C below or adnexa (direct extension or metastasis) and/or cancer cells in ascites or peritoneal washings | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1a (IA): Tumor limited to one fallopian tube, without penetrating the serosal surface; no ascites (TNM category and FIGO stage) (fallopian tube) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT2: Tumor more than 2 cm but not more than 4 cm in greatest dimension (lip and oral cavity) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Vascularization of tumor tissue (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Lymphoma extent of involvement not specified (finding) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Venous invasion cannot be assessed | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 4 | 
| pT4b: Tumor invades skull base and/or pterygoid plates and/or encases carotid artery (major salivary glands) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 |